"Synchronization of Noisy Circadian Oscillators"
Frank Doyle, UC Santa Barbara
Circadian timekeeping by intracellular molecular clocks is found throughout nature. The clockworks are driven by autoregulatory feedback loops that lead to oscillating levels of components whose maxima are in fixed phase relationships with one another. These phase relationships are the key metric characterizing the operation of the clocks. In this talk I will describe key results in capturing these behaviors with mathematical models, including their noise properties. Analysis results will be provided using wavelets for data analysis, and global sensitivity methods. Abstractions of the biophysical models will then be used to generate theorems on the interplay of local and global driving forces and the impact of the rate of synchronization.
Frank Doyle is a professor of chemical engineering and holder of the Mellichamp Chair in Process Control at the University of California, Santa Barbara, where is also director of the Institute for Collaborative Biotechnologies and associate dean of research in the college of engineering. His research interests include biosystems analysis and control, biomedical control systems synthesis, the application of advanced control schemes to nonlinear, multivariable, constrained industrial processes, the characterization of process nonlinearity for control-relevant design, large-scale applications of MPC, and experimental studies of nonlinear model-based control of particle size distribution in a semi-batch emulsion polymerization reactor. He received his PhD in chemical engineering from Caltech in 1991.